Inflammatory rheumatism and nasal polyposis
Identifieur interne : 002936 ( Main/Exploration ); précédent : 002935; suivant : 002937Inflammatory rheumatism and nasal polyposis
Auteurs : M. Laroche [France] ; E. Ginesty [France] ; E. Serrano [France] ; A. Cantagrel [France] ; E. Bon [France] ; L. Moulinier [France] ; B. Mazieres [France]Source :
- Clinical Rheumatology [ 0770-3198 ] ; 1997-03-01.
English descriptors
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Abstract
Summary: We report five cases of seronegative inflammatory rheumatism associated with nasal polyposis. The patients were four women and one man, mean age 49.5 years (range 42 – 59 yrs.). Two patients had polyarthralgia predominating in the hands, wrists and knees and two patients had symmetrical acromelic polyarthritis. The fifth patient, a woman, had oligoarticular arthritis. In a single female patient, X-rays showed moderate erosions of both tarsometatarsal bones. The inflammatory syndrome was moderate with mean ESR 23 (12 – 38) and immunological investigations were negative except for the presence of pANCA (50 – 200 U) in three patients. HLA - A1, B8, and Bw35 antigens were found in three of the five patients. In all cases, nasal and sinus polyposis (NSP) preceded rheumatism and the joint symptoms were accompanied by worsening of the ENT symptoms. NSP was confirmed by CT scan of the nasal fossae and sinuses. Polyps were surgically removed in four patients and the histology showed neither granuloma nor vasculitis. In four patients the joint symptoms, which responded poorly to nonsteroidal anti-inflammatory drugs (NSAIDs), improved markedly after ENT treatment (surgery and topical steroids) and synthetic antimalarials. The concomitant course of the joint and ENT symptoms suggests there may be a link between inflammatory rheumatism and NSP.
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DOI: 10.1007/BF02247852
Affiliations:
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The patients were four women and one man, mean age 49.5 years (range 42 – 59 yrs.). Two patients had polyarthralgia predominating in the hands, wrists and knees and two patients had symmetrical acromelic polyarthritis. The fifth patient, a woman, had oligoarticular arthritis. In a single female patient, X-rays showed moderate erosions of both tarsometatarsal bones. The inflammatory syndrome was moderate with mean ESR 23 (12 – 38) and immunological investigations were negative except for the presence of pANCA (50 – 200 U) in three patients. HLA - A1, B8, and Bw35 antigens were found in three of the five patients. In all cases, nasal and sinus polyposis (NSP) preceded rheumatism and the joint symptoms were accompanied by worsening of the ENT symptoms. NSP was confirmed by CT scan of the nasal fossae and sinuses. Polyps were surgically removed in four patients and the histology showed neither granuloma nor vasculitis. In four patients the joint symptoms, which responded poorly to nonsteroidal anti-inflammatory drugs (NSAIDs), improved markedly after ENT treatment (surgery and topical steroids) and synthetic antimalarials. The concomitant course of the joint and ENT symptoms suggests there may be a link between inflammatory rheumatism and NSP.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Midi-Pyrénées</li><li>Occitanie (région administrative)</li></region><settlement><li>Toulouse</li></settlement></list><tree><country name="France"><region name="Occitanie (région administrative)"><name sortKey="Laroche, M" sort="Laroche, M" uniqKey="Laroche M" first="M." last="Laroche">M. Laroche</name></region><name sortKey="Bon, E" sort="Bon, E" uniqKey="Bon E" first="E." last="Bon">E. Bon</name><name sortKey="Cantagrel, A" sort="Cantagrel, A" uniqKey="Cantagrel A" first="A." last="Cantagrel">A. Cantagrel</name><name sortKey="Ginesty, E" sort="Ginesty, E" uniqKey="Ginesty E" first="E." last="Ginesty">E. Ginesty</name><name sortKey="Mazieres, B" sort="Mazieres, B" uniqKey="Mazieres B" first="B." last="Mazieres">B. Mazieres</name><name sortKey="Moulinier, L" sort="Moulinier, L" uniqKey="Moulinier L" first="L." last="Moulinier">L. Moulinier</name><name sortKey="Serrano, E" sort="Serrano, E" uniqKey="Serrano E" first="E." last="Serrano">E. Serrano</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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